"One of the most valuable things we can do for one another, is listen to each other's stories." Rebecca Falls

I am very happy with the second edition of my book "Up the Creek with a Paddle, Beat MS and All Autoimmune Disorders with Low Dose Naltrexone."

It is an easy and educational read with plenty of humor to balance the pain. The second edition far exceeds the first, mainly because it is supported by: Dr. Bihari, the founder of LDN, Dr Gluck, the champion of LDN and my brother Dr. Phil Boyle who continues to find new uses for the drug. I think my writing modestly improved also. My spelling and grammar definitely did.

"Up the Creek" is first and foremost, a love story. A story of hope that details how a cheap, simple, nightly pill stopped Noel's (my husband) Primary Progressive Multiple Sclerosis in the nick of time, back in September 2002. The book humanizes the complexities of getting an FDA approved drug recognized for a new use and in the hands of people who desperately need it as much as we did. The implications extend far beyond the MS community. This book is a must for anyone who knows anybody with a disturbed immune system.

Writing and updating "Up the Creek" has always been a labor of love. It is a story the world must hear, one person at a time. I am relying on all of you to help me and realize that I need all the help I can get. I need your help.

My hope is that everyone who reads the book will pass it on because everyone knows somebody who needs to hear the story .. yesterday. I mean that with my heart and soul. If LDN has helped you, I hope that this book tells some part of your story. I kept the book as cheap as possible in the hope that it will reach more people. It contains everything anyone needs to know about LDN and could help millions of people on their journey. This book can save lives.

If you are part of a charity organization and would like to help me, for every book you sell through your charity I will donate $2 to your cause. Please contact me for details on how we could set that up.

Finally, if you know of any newspaper, radio or TV personalities who would be interested in the story, please contact me so I can try to get an interview. I love interviews and debates and could go fifteen rounds with the best. If you have personal contacts that you would be willing to share .. I would be forever grateful. It would be nice to make the movie before Pierce Brosnan gets too old to play Noel.

I am delighted to report that Noel has not experienced any new MS symptoms since he started LDN in September 2002, almost six years ago. He is in fact, healthier than most people I know. His cholesterol, liver enzymes and all of his blood tests are perfect. His doctor even told him that apart from the fact he has MS, he is in perfect shape.

I have no doubt that stress contributes to MS exacerbations because I have seen the correlation too many times, and it is fair to say that during the years post LDN, life has thrown us our fair share of stress. As a result of such hits, the pre-existing symptoms in Noels legs are a little worse. For example, he now needs two canes to get around. He has also lost some muscle tone because he uses his legs less and walks in such a way that the muscles he needs have weakened from lack of use. All of this is in keeping with the initial promise made to us by Dr. Bihari. He said that we will never experience a day post LDN, worse than our worst day pre LDN. Pre LDN, our worst days involved Noel's MS spreading up his body. His hands were starting to show symptoms, as were other areas of his body. To be quite honest, I often feel like we are now living with an injury of old, as opposed to a progressive degenerative disease. Today, Noel's MS remains confined to his legs and bladder - and some days are better than others. Exercise and physical therapy definitely help, as does a healthy diet. I am only talking about a commonsense healthy diet; low in meat, high in fresh fish, fruit and vegetables. We have definitely noticed that if Noel eats well and exercises, he feels better, but that is hardly rocket science or remotely ground-breaking.

Noel is still the primary breadwinner of our family. He is still totally independent in every way and still lives a fully functional married life. We found LDN in the nick of time and continue to encourage everybody with an autoimmune disease to try it. Noel is now as much of an advocate as I am.

My book "Up the Creek" has helped many people make that difficult decision to go against their Neurologist in his suit and fancy office, and listen to strangers on the Internet who know better because they have lived the same needless nightmare. I am very proud of the impact "Up the Creek" has had on people. It is a personal story that is absolutely worth sharing.

My uncle, Neilus, with Parkinsons Disease (PD) also started 4.5 mg LDN in September 2002. His PD has progressed. He has experienced some new symptoms, but we firmly believe that LDN is slowing the progression. It is certainly not doing him any harm so he will continue to take it. I spoke with Dr. Bihari about this and he told me that some of his other PD patients also progressed but others did not. LDN works for PD but how well is still the question. Does it slow it or stop it? I don't know yet, but I know that it definitely helps. My uncle went for his annual physical recently and all of his bloodwork is perfect. He also went to see one of the top Neurologists in NY who was very surprised that my uncle had PD for so long and had progressed so little. Naturally, he did not credit LDN. He said that my uncle was one of the lucky few. Nelius tried taking Parcopa for a while to see if it would help his shake. It didn't help him so once again he is only taking LDN to fight his PD. There are times when I look at Nelius and cant tell that he has PD, so it has to be working.

My mother with breast cancer died on August 6th 2007. She also started 4.5mg LDN in September 2002. She started LDN after a mastectomy and months of the standard recommended chemotherapy and radiation. Despite LDN, her cancer spread to her bones and then to her brain. Last summer, I went back to Ireland to care for her during her final months. I scoured the Internet to try to find something that would save her. I mean, against all odds we beat PPMS, so surely there is something out there universally beating cancer.

I believe I found the answer, too late for Mom but in the nick of time for others. I am about to publish the whole story. It's called Going Nowhere? Mom's final lesson: How to beat cancer. We tried everything on the Internet and I learned first hand why many theories out there are controversial, but I also stumbled on a fascinating theory based on an already approved generic drug that once again, nobody will profit from. The doctor who came up with this cancer theory reminds me a lot of Dr. Bihari. His name is Dr Jurkovic from Slovakia, and here is the kicker: To make his theory even better he was exhausting methods of boosting the immune system. Nothing boosts the immune system like LDN. LDN was the missing piece to his puzzle. By combining the Bihari and Jurkovic theories and protocols, I'm certain we've struck gold. Time will tell for sure but since my mother passed, two friends with advanced cancer are certainly benefiting from what we learned. Please God, they will continue to do so for many, many years to come. To understand more please visit http://www.jurkovic.sk/files/jurkovic-bmn-av.pdf

My mother's story details her final year, her faith and all the graces she was granted in her final months through the power of prayer. She died exactly right. No medicine, not even LDN, will keep anybody alive forever, so when my time comes to pass, I am grateful that my mother taught me how to die right. There is no finer lesson in life.

Happy New Year Everyone! Much has happened since I last wrote. Noel and I traveled to California in September 2006 to help raise funds for LDN research. LDN research continues to gain momentum. It is very exciting. For full details please visit http://www.ldninfo.org/ldn_latest_news.htm

So many people have emailed me wondering how Noel, Neilus and Mom are doing. My husband Noel continues to take 4.5mg LDN nightly and I am happy to report that he has not experienced one brand new symptom since he started taking LDN in September 2002. His PPMS remains in complete remission and he continues to enjoy a full independent life. He is still the sole breadwinner of our family and happier than most people I know. Noel uses a wheelchair when we are out and about but it stays in his car when he gets home because he relies on his cane around the house. Lately Noel has started to experiment with his diet and has discovered that he feels much stronger when he adheres to the best bet diet. He does not stick to the diet religiously as a rule, but when he does, he feels better. Now that we are certain that the progression has stopped we think it might be interesting to discover the benefits of diet and exercise to see if he can gain any more strength back in his legs. Once again .. time will tell. We don't seem to be in a crazy hurry to fully experiment so that must mean that life is pretty good.

We traveled to Ireland to spend Christmas 2006 with our family and I met my uncle Neilus. He has not experienced one brand new symptom since he started LDN in September 2002. I am delighted to report that his Parkinson's remains in remission and he continues to work 12 hour days at the boat yard in Downings. He looks amazing. The existing tremor in his arm and leg are worse under stress, but the bottom line is, he has not progressed and has avoided all conventional Parkinson's medications to date.

The reason we visited Ireland for Christmas was because my Mother's Cancer returned yet again with a vengeance. Despite 4.5mg LDN, her cancer once again became very active in October 2006. It took control of her very quickly. Convinced she was dying, she said all of her farewells. Her scans revealed that her cancer was manifest throughout her skeleton and had spread to the soft tissue but was not detectable in any major organ at the time. To manage her pain, Mom went on morphine. Her Oncologist offered her chemotherapy but Mom didn't want any more chemo. Mentally and physically she could not tolerate any more chemo. Once again we were in dire straits. I contacted Dr. Bihari, Dr. Gluck and Dr. Zagon. In the last chapter of my book "Up the Creek" I wrote that Dr Bihari wanted Mom to try Metenkephalin when her breast cancer spread to her bones. At that time, Mom decided that she would try chemotherapy instead. This time, Mom wanted to try anything except chemotherapy. I cannot thank Dr. Zagon, Dr. Gluck and Dr. Bihari enough for guiding me yet again. Dr Zagon hooked me up with a colleague of his in Israel and Dr Gluck hooked me up with a professor in Chicago. Between everybody we came up with a treatment regime for Mom. On November 9th 2006, Mom started to take Metenkephalin which is also called Opioid Growth Factor (OGF). OGF is the end result of the LDN research to date. With LDN for example, we are increasing the body's own OGF - but there is only so much that can be done. Some cancers don't respond to LDN. The theory is that the administration of exogenous OGF means we are adding far more than her body can ever manufacture. The hope is that such action will treat even the most aggressive cancers.

We sourced the OGF from Israel. Using a diabetic needle my father injects mom twice a day with OGF. She has had no adverse side effects from the shots. She feels good after them. From Israel we order 180mg OGF in 30ml monthly solution. So that means that there is 6mg in one ml. Using a diabetic needle dad subcutaneously injects Mom with 6ml twice daily. That would be 3.6mg OGF twice daily. Initially she also took 200mg noscapine 5 times a day. It could be that the noscapine boosted the OGF effect. We are not sure. We do know that Mom came back from the brink and we enjoyed the best Christmas ever. Her appetite and energy returned and her blood work started to fall into line. She came off morphine and now uses difene to manage her pain. On January 10th Mom stopped taking the noscapine. We are going to monitor her very closely and see if the OGF alone will maintain her. She feels very good, indicating we must be on the right track. Mom has also changed her diet. My father spends most of the day preparing her meals. It takes a lot of work to eat right. She is trying to eat an alkaline diet. This involves lots of fresh raw vegetables and juicing. She is also taking many vitamins and supplements such as acidophillus, cod liver oil, vitamin b, evening primrose, selenium, vitamin c, magnesium, calcium, vitamin e, zinc and lecithin. Her next round of scans are scheduled for March. Please God they will show the shrinkage we all feel is taking place. To try this promising therapy you need a Doctor to agree to the plan. Mom was most fortunate in that regard. She feels very good after the shots so the therapy certainly offers the patient a high quality of life. That is important to me. Time will tell what will happen next but today is a wonderful day. I have learned to live life one day at a time.

It is over a year now since my book Up The Creek With a Paddle was published. Noel continues to thrive. He has not experienced any new symptoms since he started LDN in September 2002. My uncle with Parkinson's Disease also remains stable. Under stress old symptoms flare up, but neither Noel nor Neilus, has progressed. That is the bottom line.

My mom finished all conventional treatment for her bone cancer and is back on LDN. This time she is not using calcium carbonate as the filler. She is taking 4.5mg LDN with lactose filler. It has been theorized that LDN failed her the first time, because the calcium carbonate filler made the drug slow release. Only time will prove the theory one way or another. Please God, Mom will remain as strong as she is today for many years to come.

The first LDN conference was held on June 11th 2005 in NY. I was honored to be invited to speak as the final LDN advocate. To hear my talk click here Mary Bradley 2005 For all other talks click here LDN Conference 2005

The 2nd LDN conference was held in Bethesda MD on April 7th 2006. I also spoke there as did my brother Dr Phil Boyle who is now having mind blowing results in Ireland with his patients on LDN. To hear and read about the details of the conference, click here LDN Conference 2006. The most exciting news to date is that the first scientific results for LDN have finally been published. Dr Jill Smith from Penn State university followed through with the LDN trial and has received further funding to fully evaluate the positive effect LDN has on active Crohns Disease. To read more click LDN Latest News

I would especially like to thank Dr Skip and his wife Cyndi and their son Adam for their altruistic efforts in spreading the LDN word. For information on the first LDN DVD compiled by the Lenz family which will help many people persuade their doctor to give LDN a try, click here Skips Pharmacy.

I speak about LDN on every opportunity and never refuse an invite to share my story. I have spoken at many MS meetings. I feel we have come a long, long way. I will be in Ireland for two weeks in July 2006 where I will once again try to get on as many airwaves as possible to keep the LDN word spreading.

Sincere thanks to everyone I have met on this journey for all of your encouraging words of support. Book proceeds have so far been spent on buying more books to keep the LDN word spreading.